When choosing or editing a gaming or anime PFP, focus on a clear silhouette and...

https://purepfp.com/why-bold-game-characters-remain-recognisable-in-tiny-profile-icons/

When choosing or editing a gaming or anime PFP, focus on a clear silhouette and good contrast to make the image pop when shrunk down. Crop tightly around the face, keep backgrounds simple, and avoid text